P站视频

Skip to main content

What Causes Pancreatic Neuroendocrine Tumor?

Scientists don’t know exactly what causes most pancreatic neuroendocrine tumors (NETs), but they have found several risk factors that can make a person more likely to get this disease. Some of these risk factors affect the DNA of cells in the neuroendocrine system in the pancreas, which can result in abnormal cell growth and may cause cancers to form.

DNA is the chemical in our cells that carries our genes, which control how our cells function. We look like our parents because they are the source of our DNA. But DNA affects more than just how we look.

Some genes control when our cells grow, divide into new cells, and die:

  • Genes that help cells grow, divide, and stay alive are called oncogenes.
  • Genes that help keep cell division under control, repair mistakes in DNA, or cause cells to die at the right time are called tumor suppressor genes.

Cancers can be caused by DNA changes (mutations) that turn on oncogenes or turn off tumor suppressor genes.

Inherited gene mutations

Although 90% of PNETs are sporadic (random), some people inherit gene changes from their parents that raise their risk of pancreatic NET. Sometimes these gene changes are part of syndromes that include increased risks of other health problems as well.

Syndromes related to changes in three tumor suppressor genes are responsible for many inherited cases of pancreatic NETs:

  • Multiple Endocrine Neoplasia Type 1 (MEN1) syndrome: Most inherited cases of PNETs are due to changes in the MEN1 gene. This syndrome can cause cancer in the pancreas, parathyroid glands, and pituitary glands. These tumors usually happen at younger ages and tend to be non-functioning. Screening people with the MEN1 gene or their family members can sometimes help find pancreatic NET before symptoms appear.
  • Von Hippel-Lindau (VHL) syndrome: Changes in the VHL gene cause a small number of pancreatic NETs, usually developing at earlier ages (sometimes as early as the 20s). These tumors tend to be non-functioning and slow growing.
  • Neurofibromatosis type 1 (NF1) syndrome: A small number of pancreatic NETs (usually somatostatinomas) are caused by changes in the NF1 gene. Other cancers are also associated with this syndrome, including brain tumors or benign tumors that form in nerves under the skin (neurofibromas),

The treatment for a pancreatic NET that's caused by a genetic syndrome might be slightly different compared to treatment for a pancreatic NET in someone without a gene mutation.

Acquired gene mutations

Most gene mutations related to neuroendocrine tumors of the pancreas are caused by random changes. These random mutations are called acquired if they occur after a person is born, rather than having been inherited. These acquired gene mutations sometimes result from exposure to cancer-causing chemicals (like those found in tobacco smoke). But often what causes these changes is not known.

The P站视频 medical and editorial content team

Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as editors and translators with extensive experience in medical writing.

Benafif S and Eeles R. Diagnosis and Management of Hereditary Carcinoids. Recent Results Cancer Res. 2016; 205:149-68. doi: 10.1007/978-3-319-29998-3_9.

Chai SM, Brown IS, Kumarasinghe MP. Gastroenteropancreatic neuroendocrine neoplasms: selected pathology review and molecular updates. Histopathology. 2018 Jan;72(1):153-167. doi: 10.1111/his.13367.

Chen M, Van Ness M, Guo Y, Gregg J. Molecular pathology of pancreatic neuroendocrine tumors. Journal of Gastrointestinal Oncology. 2012;3(3):182-188. doi:10.3978/j.issn.2078-6891.2012.018.

Friedman JM. Neurofibromatosis 1. 1998 Oct 2 [Updated 2018 May 17]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews? [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1109/

Lee J, Allendorf J, Chabot J. Surgical resection of sporadic pancreatic neuroendocrine tumors. UpToDate website. https://www.uptodate.com/contents/surgical-resection-of-sporadic-pancreatic-neuroendocrine-tumors. Updated January 09, 2018. Accessed October 3, 2018. 

van Leeuwaarde RS, Ahmad S, Links TP, et al. Von Hippel-Lindau Syndrome. 2000 May 17 [Updated 2018 Sep 6]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews? [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1463/

Vinik A, Perry RR, Hughes MS, et al. Multiple Endocrine Neoplasia Type 1. [Updated 2017 Oct 7]. In: De Groot LJ, Chrousos G, Dungan K, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK481897/. Accessed 10.02.18.

Yao JC, Evans DB. Chapter 85: Pancreatic neuroendocrine tumors. In: DeVita VT, Lawrence TS, Rosenberg SA, eds. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2015.

Last Revised: October 30, 2018

P站视频 Emails

Sign up to stay up-to-date with news, valuable information, and ways to get involved with the P站视频.