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What's New in Adrenal Cancer Research?

Important research on adrenal cancer currently is being done in hospitals and institutions around the world. Scientists are learning more about what causes the disease and how best to treat it. Progress in this research, however, tends to be slow because adrenal cancer is so rare.

Chemotherapy

Although adrenal cancer can be hard to study, experts are looking for new drugs that may help, as well as looking at the value of current treatments.

Ongoing studies are looking at which chemotherapy combinations would allow for the best treatment outcomes, but the lowest risk for side effects.

Targeted therapy

Researchers are working to understand the genetic changes that cause adrenal cancers so that newer treatments to target these changes can be found.

Targeted therapy  uses drugs to attack the programming that makes cancer cells different from normal, healthy cells. Each type of targeted therapy works differently, but all alter the way a cancer cell grows, divides, repairs itself, or interacts with other cells. 

Researchers are continuing to study targeted drugs, such as IGF1R inhibitors, VEGFR inhibitors, and EGFR inhibitors. So far, they have not found a way to make them very effective. 

Genetics

Scientists are learning how changes in certain genes cause normal adrenal cortex cells to become cancerous. Understanding these genetic changes will help doctors develop better methods to diagnose this disease, as well as treatments that are more effective and have fewer side effects than those currently available. Medical centers involved in research might ask their patients for blood samples and about diseases in other family members to learn more about adrenal cancer.

 The goal of these studies is to learn more about how adrenal cancer forms, and in the future find new targets for adrenal cancer therapy. For example, there have been several studies looking at which hereditary syndromes, such as Lynch syndrome, lead to a higher risk for adrenal cancer. (These syndromes are discussed in Risk Factors for Adrenal Cancer.)

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Developed by the P站视频 medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).

 

Bancos I, Prete A. Approach to the Patient With Adrenal Incidentaloma. J Clin Endocrinol Metab. 2021 Oct 21;106(11):3331-3353. 

Corssmit EPM, Dekkers OM. Screening in adrenal tumors. Curr Opin Oncol. 2019 May;31(3):243-246. 

Ghosh C, Hu J, Kebebew E. Advances in translational research of the rare cancer type adrenocortical carcinoma. Nat Rev Cancer. 2023 Dec;23(12):805-824.  Epub 2023 Oct 19. PMID: 37857840.

Zheng S, Cherniack AD, Dewal N, Moffitt RA, Danilova L, et al. Cancer Genome Atlas Research Network; Hammer GD, Giordano TJ, Verhaak RGW. Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma. Cancer Cell. 2016 May 9;29(5):723-736. doi: 10.1016/j.ccell.2016.04.002. Erratum in: Cancer Cell. 2016 Aug 8;30(2):363. 

 

Last Revised: October 1, 2024

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